Benign fibrous histiocytoma of the oral and maxillofacial region: A systematic review

Laura Borges Kirschnick; Lauren Frenzel Schuch; Felipe Martins Silveira; Bruna Barcelos Só; Marco Antonio Trevizani Martins; Márcio Ajudarte Lopes; Pablo Agustin Vargas; Alan Roger Santos-Silva; Vinicius Coelho Carrard; Ana Carolina Uchoa Vasconcelos; Vivian Petersen Wagner; Manoela Domingues Martins

doi:10.1016/j.oooo.2021.07.003

Benign fibrous histiocytoma of the oral and maxillofacial region: A systematic review

Oral Surg Oral Med Oral Pathol Oral Radiol. 2022 Feb;133(2):e43-e56. doi: 10.1016/j.oooo.2021.07.003. Epub 2021 Jul 15.

Affiliations

¹ Oral Diagnosis Department, Piracicaba Dental School, Universidade Estadual de Campinas, Piracicaba, São Paulo, Brazil.
² Department of Oral Pathology, Dental School, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil.
³ Department of Oral Pathology, Dental School, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil; Department of Oral Medicine, Hospital de Clínicas de Porto Alegre (HCPA/UFRGS), Porto Alegre, Rio Grande do Sul, Brazil.
⁴ Diagnostic Center for Oral Diseases, Dental School, Universidade Federal de Pelotas, Pelotas, Rio Grande do Sul, Brazil.
⁵ Academic Unit of Oral and Maxillofacial Medicine and Pathology, Department of Clinical Dentistry, University of Sheffield, Sheffield, UK.
⁶ Oral Diagnosis Department, Piracicaba Dental School, Universidade Estadual de Campinas, Piracicaba, São Paulo, Brazil; Department of Oral Pathology, Dental School, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil; Department of Oral Medicine, Hospital de Clínicas de Porto Alegre (HCPA/UFRGS), Porto Alegre, Rio Grande do Sul, Brazil. Electronic address: Manomartins@gmail.com.

PMID: 34511357
DOI: 10.1016/j.oooo.2021.07.003

Abstract

Objective: The aim of the present study was to carry out a systematic review of available data regarding case reports and case series of oral and maxillofacial benign fibrous histiocytoma (BFH).

Study design: A search strategy was performed using the PubMed, Web of Science, Scopus, and EMBASE electronic databases.

Results: Male individuals (56.89%) were more affected, with a mean age of 34.55 ± 20 years. The buccal mucosa (20.33%) represented the most common site, with the clinical presentation of a painless (86.95%) nodule (98.03%). The clinical hypothesis of a fibroma was reported in most cases (31.57%). Radiographic presentation of intraosseous lesions showed multilocular radiolucent images (55.55%). Regarding the histopathologic features, the biphasic population of fibroblastic and histiocytic cells was seen in 21 cases (39.62%), and a spindle-shaped fibroblastic cell population organized into a storiform pattern was observed in 25 cases (47.16%). CD68 (n = 26) and vimentin (n = 25) showed immunoreactivity in all BFH cases in which they were used. All cases were treated with a surgical resection, and 8.10% recurred.

Conclusions: The current systematic review demonstrated that BFH represents a rare lesion that mainly affects the buccal mucosa of male individuals, and the treatment is mainly surgical with a good prognosis.

Publication types

Research Support, Non-U.S. Gov't
Review
Systematic Review

MeSH terms

Adolescent
Adult
Head
Histiocytoma, Benign Fibrous* / diagnostic imaging
Histiocytoma, Benign Fibrous* / pathology
Histiocytoma, Benign Fibrous* / surgery
Humans
Male
Middle Aged
Neoplasm Recurrence, Local
Young Adult