Outcomes of salvage treatment in patients with recurrent oral squamous cell carcinoma

Tseng-Cheng Chen; Ta-Hsuan Lo; Huai-Cheng Huang; Chun-Wei Wang; Tsung-Lin Yang; Pei-Jen Lou; Jenq-Yuh Ko; Cheng-Ping Wang

doi:10.1002/hed.26862

Outcomes of salvage treatment in patients with recurrent oral squamous cell carcinoma

Head Neck. 2021 Dec;43(12):3764-3774. doi: 10.1002/hed.26862. Epub 2021 Sep 12.

Authors

Tseng-Cheng Chen¹, Ta-Hsuan Lo¹, Huai-Cheng Huang², Chun-Wei Wang³, Tsung-Lin Yang¹, Pei-Jen Lou¹, Jenq-Yuh Ko¹, Cheng-Ping Wang¹

Affiliations

¹ Department of Otolaryngology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan.
² Department of Oncology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan.
³ Division of Radiation Oncology, Department of Oncology, National Taiwan University Hospital, Taipei, Taiwan.

PMID: 34510614
DOI: 10.1002/hed.26862

Abstract

Background: The survival outcomes of different salvage treatments for patients with recurrent oral cancer remain unclear.

Methods: A total of 556 patients with recurrent oral cancer between 2010 and 2015 were reviewed. Clinical/pathological risk factors and different salvage treatments were analyzed.

Results: The 2-year disease-free survival rates after recurrence in patients not receiving salvage operation (305 patients), receiving salvage operation with (121 patients), and without (130 patients) major pathological risk factors (margin or extranodal extension) were 5.3%, 32.4%, and 77.2%, respectively (p < 0.001). The 2-year overall survival rates were 20.3%, 58.4%, and 89.2%, respectively (p < 0.001). A late-onset recurrence, salvage radiation, and salvage operation were independent factors for good disease-free and overall survival. Salvage radiation showed survival benefits among patients not indicated for salvage operations.

Conclusions: Salvage operation was the first choice for recurrent oral cancer. Patients who received the salvage operation without major risk factors had the best survival.

Keywords: disease-free survivals; overall survivals; recurrent oral cancer; salvage treatment; squamous cell carcinoma.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Carcinoma, Squamous Cell* / surgery
Head and Neck Neoplasms*
Humans
Mouth Neoplasms* / surgery
Neoplasm Recurrence, Local
Retrospective Studies
Salvage Therapy
Squamous Cell Carcinoma of Head and Neck
Survival Rate