Trimeric chalchonoids from the total phenolic extract of Chinese dragon's blood (the red resin of Dracaena cochinchinensis)

Fitoterapia. 2021 Oct:154:105029. doi: 10.1016/j.fitote.2021.105029. Epub 2021 Sep 8.

Abstract

Four new chalchonoid trimers, named cochinchinenins N-Q (1-4), along with a pair of known enantiomers (5-6), were isolated from the total phenolic extract of Chinese dragon's blood (the red resin of Dracaena cochinchinensis). The planar structures of 1-4 were elucidated by extensive spectroscopic analysis including HRESIMS and 1D/2D NMR. The absolute configurations of new compounds were established by ECD data. Compound 1 exhibited significant inhibition of nitric oxide production in lipopolysaccharide-stimulated BV-2 microglial cells with IC50 value of 11.5 ± 1.7 μM.

Keywords: BV-2 microglial; Chalchonoid trimers; Chinese dragon's blood; Dracaena cochinchinensis.

MeSH terms

  • Animals
  • Cell Line
  • Chalcones / isolation & purification
  • Chalcones / pharmacology*
  • Dracaena / chemistry*
  • Drugs, Chinese Herbal / pharmacology
  • Mice
  • Microglia / drug effects*
  • Nitric Oxide
  • Phytochemicals / isolation & purification
  • Phytochemicals / pharmacology
  • Plant Extracts / chemistry*
  • Resins, Plant / chemistry

Substances

  • Chalcones
  • Drugs, Chinese Herbal
  • Phytochemicals
  • Plant Extracts
  • Resins, Plant
  • Nitric Oxide
  • dragon's blood