Gastric Plasmacytoma with Immunoglobulin Lambda Light Chain Deposition in a Dog

Naoki Hanari; Tomokazu Nagashima; Yukino Machida; Yoshiaki Kubo; Yuji Hamamoto; Junichi Kamiie; Kazuhiko Ochiai; Daigo Azakami; Masaki Michishita

doi:10.1016/j.jcpa.2021.06.005

Gastric Plasmacytoma with Immunoglobulin Lambda Light Chain Deposition in a Dog

J Comp Pathol. 2021 Aug:187:7-10. doi: 10.1016/j.jcpa.2021.06.005. Epub 2021 Jul 20.

Authors

Naoki Hanari¹, Tomokazu Nagashima², Yukino Machida¹, Yoshiaki Kubo³, Yuji Hamamoto³, Junichi Kamiie⁴, Kazuhiko Ochiai⁵, Daigo Azakami⁶, Masaki Michishita⁷

Affiliations

¹ Department of Veterinary Pathology, Nippon Veterinary and Life Science University, Tokyo, Japan.
² Department of Veterinary Pathology, Nippon Veterinary and Life Science University, Tokyo, Japan; Veterinary Medical Teaching Hospital, Nippon Veterinary and Life Science University, Tokyo, Japan.
³ Veterinary Medical Teaching Hospital, Nippon Veterinary and Life Science University, Tokyo, Japan.
⁴ Laboratory of Veterinary Pathology, Azabu University, Kanagawa, Japan.
⁵ Research Center for Animal Life Science, Nippon Veterinary and Life Science University, Tokyo, Japan; Department of Veterinary Hygiene, Nippon Veterinary and Life Science University, Tokyo, Japan.
⁶ Laboratory of Veterinary Clinical Oncology, Tokyo University of Agriculture and Technology, Tokyo, Japan.
⁷ Department of Veterinary Pathology, Nippon Veterinary and Life Science University, Tokyo, Japan; Research Center for Animal Life Science, Nippon Veterinary and Life Science University, Tokyo, Japan. Electronic address: michishita@nvlu.ac.jp.

PMID: 34503657
DOI: 10.1016/j.jcpa.2021.06.005

Abstract

A 12-year-old castrated male Jack Russell Terrier presented with intermittent vomiting. Abdominal ultrasonographic examination detected a thickened stomach wall with a mass measuring approximately 1.5 cm in diameter. Computed tomography revealed a solitary mass measuring approximately 2.1 cm in diameter between the submucosa and muscle layers in the greater curvature the pyloric region of the stomach, and a swelling in the hepatic lymph node. The gastric mass was composed of round neoplastic cells arranged in a diffuse pattern. The neoplastic cells had a round nucleus and a pale abundant cytoplasm. Multinucleated giant cells were often found. Hyalinized eosinophilic material, which did not stain with Congo red and had no affinity for thioflavin T, was also observed. Neoplastic cells were immunopositive for MUM1, CD79a and Ig lambda light chain but negative for CD3, CD20, BLA36, IgG and Ig kappa light chain. Stromal eosinophilic material was positive for Ig lambda light chain. The neoplasm was therefore diagnosed as a gastric plasmacytoma with non-amyloid Ig lambda light chain deposition.

Keywords: dog; lambda light chain; plasmacytoma; stomach.

Publication types

Case Reports

MeSH terms

Animals
Dog Diseases*
Dogs
Immunoglobulin lambda-Chains
Immunoglobulins
Male
Plasmacytoma* / veterinary
Stomach Neoplasms* / veterinary
Tomography, X-Ray Computed

Substances

Immunoglobulin lambda-Chains
Immunoglobulins