Polyisobutylene-New Opportunities for Medical Applications

Molecules. 2021 Aug 27;26(17):5207. doi: 10.3390/molecules26175207.

Abstract

This paper presents the results of the first part of testing a novel electrospun fiber mat based on a unique macromolecule: polyisobutylene (PIB). A PIB-based compound containing zinc oxide (ZnO) was electrospun into self-supporting mats of 203.75 and 295.5 g/m2 that were investigated using a variety of techniques. The results show that the hydrophobic mats are not cytotoxic, resist fibroblast cell adhesion and biofilm formation and are comfortable and easy to breathe through for use as a mask. The mats show great promise for personal protective equipment and other applications.

Keywords: COVID mask; biofilm formation; cell adhesion; electrospinning; fiber mat; polyisobutylene.

MeSH terms

  • Biofilms / drug effects
  • Cell Adhesion / drug effects
  • Cells, Cultured
  • Fibroblasts / drug effects
  • Humans
  • Materials Testing / methods
  • Nanofibers / chemistry
  • Polyenes / chemistry*
  • Polymers / chemistry*
  • Zinc Oxide / chemistry

Substances

  • Polyenes
  • Polymers
  • polyisobutylene
  • Zinc Oxide