Abstract
Endogenous peptides and structurally similar bacterial heat-stable enterotoxins (ST) bind guanylate cyclase-C (GC-C), resulting in fluid homeostasis or diarrhea, respectively. In this issue of Cell Host & Microbe, Carey et al., show how bats have evolutionarily maintained homeostatic signaling while avoiding pathogenic effects of ST.
Published by Elsevier Inc.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Animals
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Bacterial Toxins / metabolism*
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Chiroptera
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Cyclic GMP / metabolism
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Cyclic GMP-Dependent Protein Kinase Type II / metabolism*
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Cystic Fibrosis Transmembrane Conductance Regulator / metabolism
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Diarrhea / microbiology
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Diarrhea / pathology
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Enterocytes / metabolism
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Enterotoxigenic Escherichia coli / metabolism
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Enterotoxigenic Escherichia coli / pathogenicity*
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Enterotoxins / metabolism*
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Guanylate Cyclase / genetics
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Guanylate Cyclase / metabolism*
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Protein Binding
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Signal Transduction
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Sodium-Hydrogen Exchangers / metabolism
Substances
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Bacterial Toxins
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Enterotoxins
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Sodium-Hydrogen Exchangers
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Cystic Fibrosis Transmembrane Conductance Regulator
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Cyclic GMP-Dependent Protein Kinase Type II
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Guanylate Cyclase
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Cyclic GMP