History and current trends in the treatment of idiopathic overactive bladder

Ceska Gynekol. 2021;86(4):284-290. doi: 10.48095/cccg2021284.

Abstract

Objective: Historical and current view on the therapy of overactive bladder.

Methods: This review summarizes the historical approach and current therapy of overactive bladder. The articles were gathered from Pubmed and Scopus databases. Studies published before December 2020 were used for the review.

Results and conclusion: Overactive bladder is a condition that quite a lot reduces the quality of life of our patients. Our therapeutic approach starts with non-pharmacological treatment, such as pelvic floor exercises. The next step is a pharmacological approach. The entry level drug is trospium. If the effect is not sufficient, propiverine, solifenacin, fesoterodine, darifenacin or mirabegron are used. Electrostimulation or botulinum toxin A application is an option only in cases that didnt respond to pharmacological treatment. It is safe to say, that in the end, there is a way of reducing the severity of overactive bladder symptoms for every patient.

Keywords: anticholinergics; botulinum toxin A; electrostimulation; mirabegron; overactive bladder; urgency.

Publication types

  • Review

MeSH terms

  • Benzhydryl Compounds
  • Humans
  • Muscarinic Antagonists / therapeutic use
  • Quality of Life
  • Solifenacin Succinate
  • Treatment Outcome
  • Urinary Bladder, Overactive* / therapy

Substances

  • Benzhydryl Compounds
  • Muscarinic Antagonists
  • Solifenacin Succinate