Case Report: Tropheryma whipplei Hide in an AIDS Patient With Pneumocystis Pneumonia

Jun Yan; Binhai Zhang; Zhongdong Zhang; Jinchuan Shi; Shourong Liu; Jianjiang Qi; Mengyan Wang

doi:10.3389/fpubh.2021.663093

Case Report: Tropheryma whipplei Hide in an AIDS Patient With Pneumocystis Pneumonia

Front Public Health. 2021 Aug 13:9:663093. doi: 10.3389/fpubh.2021.663093. eCollection 2021.

Authors

Jun Yan¹, Binhai Zhang¹, Zhongdong Zhang¹, Jinchuan Shi¹, Shourong Liu¹, Jianjiang Qi¹, Mengyan Wang¹

Affiliation

¹ Department II of Infectious Diseases, Xixi Hospital of Hangzhou, Zhejiang University, Hangzhou, China.

Abstract

Introduction:Pneumocystis pneumonia (PCP) is one of the most common opportunistic infections in HIV-infected patients. However, coinfection with Tropheryma whipplei is infrequent in AIDS patients with PCP. Case Presentation: We report a 28-year-old male AIDS patient coinfected with T. whipplei and Pneumocystis jirovecii diagnosed in the bronchoalveolar lavage. After sulfamethoxazole-trimethoprim and meropenem treatment, the patient showed clinical improvement in 2 weeks. Conclusion: Clinicians need to be alert to the occurrence of T. whipplei infection in AIDS patients with PCP and timely diagnosis and antibacterial treatments are essential. This case may help clinicians for timely diagnosis of the coinfection of T. whipplei and P. jirovecii in AIDS patients.

Keywords: HIV; NGS; Pneumocystis pneumonia; Tropheryma whipplei; case report.

Publication types

Case Reports
Research Support, Non-U.S. Gov't

MeSH terms

Acquired Immunodeficiency Syndrome* / complications
Adult
Humans
Male
Pneumocystis carinii*
Pneumonia, Pneumocystis* / complications
Trimethoprim, Sulfamethoxazole Drug Combination / therapeutic use
Tropheryma / genetics

Substances

Trimethoprim, Sulfamethoxazole Drug Combination