The diagnostic and prognostic value of tumor markers in giant mediastinal endodermal sinus tumor with prolonged survival: Twelve-year follow up after radical resection

Abdullah M Al Ghamdi; Othman M Al Fraih; Meenal A Al Abdulhai; Ahmed Alshaer; Yousif Al Qahtani; Natasha T Khan; Ikram Ul Haq Chaudhry

doi:10.1016/j.amsu.2021.102744

The diagnostic and prognostic value of tumor markers in giant mediastinal endodermal sinus tumor with prolonged survival: Twelve-year follow up after radical resection

Ann Med Surg (Lond). 2021 Aug 23:69:102744. doi: 10.1016/j.amsu.2021.102744. eCollection 2021 Sep.

Authors

Abdullah M Al Ghamdi¹, Othman M Al Fraih¹, Meenal A Al Abdulhai¹, Ahmed Alshaer¹, Yousif Al Qahtani¹, Natasha T Khan¹, Ikram Ul Haq Chaudhry¹

Affiliation

¹ Department of Thoracic Surgery, Dammam Medical Complex Saudi Arabia, Saudi Arabia.

Abstract

We report a case of 16 -year male who presented with nonproductive cough, chest pain, and hemoptysis. His chest -x-ray and computerized tomographic scan (CT) of the thorax with contrast enhancement revealed a large mediastinal mass mostly occupying the left hemithorax. Percutaneous CT scan-guided biopsy of the mediastinal mass was reported as an endodermal sinus tumor (EDST). Serum alpha-fetoprotein levels were markedly raised (120,000 ng/ml). After completion of chemotherapy repeat, CT scan of the thorax revealed a large residual mass. Radical resection of the tumor was carried out. Twelve-year post-surgical resection follow-up with serial serum alpha-fetoprotein (AFP) tumor marker levels and CT scan of the thorax showed no recurrence.

Keywords: Alpha-fetoprotein; Chemotherapy; Endodermal sinus tumor; Mediastinum; Surgery.

Publication types

Case Reports