Ultrasound-based one-step fabrication of nobiletin particle: A facile stabilization strategy

Xinyi Wang; Bin Zhou; Di Wu; Xiaojuan Chen; Bin Li; Ling Wang; Hongshan Liang

doi:10.1016/j.foodchem.2021.130896

Ultrasound-based one-step fabrication of nobiletin particle: A facile stabilization strategy

Food Chem. 2022 Feb 1:369:130896. doi: 10.1016/j.foodchem.2021.130896. Epub 2021 Aug 19.

Authors

Xinyi Wang¹, Bin Zhou², Di Wu¹, Xiaojuan Chen¹, Bin Li¹, Ling Wang¹, Hongshan Liang³

Affiliations

¹ College of Food Science and Technology, Huazhong Agricultural University, Wuhan 430070, China; Key Laboratory of Environment Correlative Dietology (Huazhong Agricultural University), Ministry of Education, China.
² Key Laboratory of Fermentation Engineering, Ministry of Education, Hubei University of Technology, Wuhan 430068, China; National "111" Center for Cellular Regulation and Molecular Pharmaceutics, Hubei University of Technology, Wuhan 430068, China; Hubei Key Laboratory of Industrial Microbiology, Hubei University of Technology, Wuhan 430068, China; School of Biological Engineering and Food, Hubei University of Technology, Wuhan 430068, China.
³ College of Food Science and Technology, Huazhong Agricultural University, Wuhan 430070, China; Key Laboratory of Environment Correlative Dietology (Huazhong Agricultural University), Ministry of Education, China. Electronic address: lianghongshan@mail.hzau.edu.cn.

PMID: 34482239
DOI: 10.1016/j.foodchem.2021.130896

Abstract

As a typical representative of polymethoxylated flavones, nobiletin (NOB) is beneficial to health but hard to be processed, stored, and absorbed, due to its hydrophobicity and crystallinity. Herein, we developed a stabilization system based on an efficient manufacturing procedure of NOB nanocrystal by anti-solvent method combined with ultrasonic treatment. Metal-phenolic networks composed of tannic acid and metal ions were introduced to conformally coat on formed nanocrystal for further stabilization. From the results, the size and morphology of the prepared particles could be altered by the amount, ratio, and kind of the coating materials. The optimized samples could be redispersed after centrifugation, and keep stable at 4 ℃ for at least 120 days. Moreover, they possessed higher acid stability and more effective release than the control sample during the in vitro digestion experiment. Therefore, this work provided a promising idea for overcoming storage and delivery obstacle of hydrophobic crystalline bioactive components.

Keywords: Encapsulation; Metal-phenolic networks; Nanocrystal; Nobiletin; Stabilization; Ultrasound.

MeSH terms

Flavones*
Nanoparticles*

Substances

Flavones
nobiletin