AuNPs/NiFe-LDHs-assisted laser desorption/ionization mass spectrometry for efficient analysis of metronidazole and its metabolites in water samples

Lingyu Li; Zhichang Qiu; Yuanfeng Qi; Dantong Zhao; Iftikhar Ali; Chenglong Sun; Longhua Xu; Zhenjia Zheng; Chunxia Ma

doi:10.1016/j.jhazmat.2021.126893

AuNPs/NiFe-LDHs-assisted laser desorption/ionization mass spectrometry for efficient analysis of metronidazole and its metabolites in water samples

J Hazard Mater. 2022 Feb 5;423(Pt A):126893. doi: 10.1016/j.jhazmat.2021.126893. Epub 2021 Aug 12.

Authors

Lingyu Li¹, Zhichang Qiu², Yuanfeng Qi³, Dantong Zhao⁴, Iftikhar Ali⁵, Chenglong Sun⁶, Longhua Xu², Zhenjia Zheng⁷, Chunxia Ma⁸

Affiliations

¹ Key Laboratory of Food Processing Technology and Quality Control of Shandong Higher Education Institutes, College of Food Science and Engineering, Shandong Agricultural University, 61 Daizong Street, Tai'an 271018, Shandong, PR China; Key Laboratory for Applied Technology of Sophisticated Analytical Instruments of Shandong Province, Shandong Analysis and Test Center, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250014, Shandong, PR China.
² Key Laboratory of Food Processing Technology and Quality Control of Shandong Higher Education Institutes, College of Food Science and Engineering, Shandong Agricultural University, 61 Daizong Street, Tai'an 271018, Shandong, PR China.
³ School of Environmental and Municipal Engineering, Qingdao University of Technology, Qingdao 266033, Shandong, PR China.
⁴ Heze Institute for Food and Drug Control, Heze 274000, Shandong, PR China.
⁵ Department of Chemistry, Karakoram International University, Gilgit-Baltistan, Gilgit 15100, Pakistan.
⁶ Key Laboratory for Applied Technology of Sophisticated Analytical Instruments of Shandong Province, Shandong Analysis and Test Center, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250014, Shandong, PR China.
⁷ Key Laboratory of Food Processing Technology and Quality Control of Shandong Higher Education Institutes, College of Food Science and Engineering, Shandong Agricultural University, 61 Daizong Street, Tai'an 271018, Shandong, PR China. Electronic address: zhengzhenjia@sdau.edu.cn.
⁸ Key Laboratory for Applied Technology of Sophisticated Analytical Instruments of Shandong Province, Shandong Analysis and Test Center, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250014, Shandong, PR China; School of Environmental and Municipal Engineering, Qingdao University of Technology, Qingdao 266033, Shandong, PR China. Electronic address: machunxia8927@163.com.

PMID: 34479085
DOI: 10.1016/j.jhazmat.2021.126893

Abstract

Gold nanoparticles (AuNPs) have been widely used as laser desorption/ionization mass spectrometry (LDI-MS) nanomaterials for the analysis of low-molecular-weight samples. Nickel/iron-layered double hydroxides (NiFe-LDHs) nanosheets can support the anchoring of AuNPs and enhance the ability of desorption/ionization. Their hybrid nanocomposites are expected to produce synergistic effects to improve the performance of LDI-MS. In this work, a novel AuNPs/NiFe-LDHs nanomaterial was synthesized by self-assembly method and characterized based on TEM, SEM, XPS, UV-vis and FTIR-ATR. AuNPs/NiFe-LDHs assisted LDI-TOF MS exhibited higher peak intensity and lower background noise compared with conventional organic matrices. Furthermore, excellent salt and protein tolerance, good repeatability and quantification were observed when MNZ and its metabolites were detected in the range of 1-50 ng·μL^-1 (R² > 0.98), with LODs and LOQs of 0.5 ng·μL^-1 and 1 ng·μL^-1, respectively. This nanocomposite could also be used for the analysis of some other small molecules, such as antibiotics, sugars, amino acids and pesticides, demonstrating the potential to detect a variety of environmental chemicals. Taken together, the developed method combined the advantages of two nanomaterials and can provide rapid and accurate analysis of MNZ and its metabolites in water samples, as well as some other small molecules.

Keywords: AuNPs/NiFe-LDHs; Detection; LDI-TOF MS; MNZ; Quantification.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Gold*
Hydroxides
Iron
Lasers
Metal Nanoparticles*
Metronidazole
Nickel
Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
Water

Substances

Hydroxides
Water
Metronidazole
Gold
Nickel
Iron