Abstract
1, 2, 3, 4-Tetrahydro-β-carboline (THβC) scaffold is widespread in many natural products (NPs) and synthetic compounds which show a variety of pharmacological activities. In this article, we reviewed the design, structures and biological characteristics of reported synthetic THβC compounds, and structure and activity relationship (SAR) of them were also discussed. This work might provide a reference for subsequent drug development based on THβC.
Keywords:
Activity; Modification; Structure; THβC; Target.
Copyright © 2021 Elsevier Masson SAS. All rights reserved.
MeSH terms
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Analgesics / chemical synthesis
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Analgesics / chemistry
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Analgesics / pharmacology
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Antimalarials / chemical synthesis
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Antimalarials / chemistry
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Antimalarials / pharmacology
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Antineoplastic Agents / chemical synthesis
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / pharmacology
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Antiprotozoal Agents / chemical synthesis
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Antiprotozoal Agents / chemistry
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Antiprotozoal Agents / pharmacology
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Antiviral Agents / chemical synthesis
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Antiviral Agents / chemistry
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Antiviral Agents / pharmacology
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Carbolines / chemical synthesis*
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Carbolines / chemistry
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Carbolines / pharmacology
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Chemistry, Pharmaceutical
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Fungicides, Industrial / chemical synthesis
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Fungicides, Industrial / chemistry
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Fungicides, Industrial / pharmacology
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Humans
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Molecular Structure
Substances
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Analgesics
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Antimalarials
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Antineoplastic Agents
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Antiprotozoal Agents
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Antiviral Agents
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Carbolines
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Fungicides, Industrial
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tryptoline