Come one, come all? Re-evaluating RNA polymerase II pre-initiation complex assembly using single-molecule microscopy

Tim Y Hou; W Lee Kraus

doi:10.1016/j.molcel.2021.08.012

Come one, come all? Re-evaluating RNA polymerase II pre-initiation complex assembly using single-molecule microscopy

Mol Cell. 2021 Sep 2;81(17):3443-3445. doi: 10.1016/j.molcel.2021.08.012.

Authors

Tim Y Hou¹, W Lee Kraus²

Affiliations

¹ Laboratory of Signaling and Gene Regulation, Cecil H. and Ida Green Center for Reproductive Biology Sciences, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Division of Basic Research, Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
² Laboratory of Signaling and Gene Regulation, Cecil H. and Ida Green Center for Reproductive Biology Sciences, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Division of Basic Research, Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. Electronic address: lee.kraus@utsouthwestern.edu.

PMID: 34478651
DOI: 10.1016/j.molcel.2021.08.012

Abstract

Complementary papers by Nguyen et al. (2021) and Baek et al. (2021) track the assembly of the pre-initiation complexes at gene promoters using single-molecule microscopy, revealing dynamic spatiotemporal regulation of transcription initiation.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Comment

MeSH terms

Promoter Regions, Genetic
RNA Polymerase II* / genetics
RNA Polymerase II* / metabolism
Single Molecule Imaging*

Substances

RNA Polymerase II