Inflation comes before the fall: How epithelial stretch drives crypt fission

Geraldine M Jowett; Eileen Gentleman

doi:10.1016/j.stem.2021.08.008

Inflation comes before the fall: How epithelial stretch drives crypt fission

Cell Stem Cell. 2021 Sep 2;28(9):1505-1506. doi: 10.1016/j.stem.2021.08.008.

Authors

Geraldine M Jowett¹, Eileen Gentleman²

Affiliations

¹ Centre for Craniofacial and Regenerative Biology, King's College London, London SE1 9RT, UK; Wellcome Trust/Cancer Research UK Gurdon Institute, Henry Wellcome Building of Cancer and Developmental Biology, Cambridge CB2 1QN, UK.
² Centre for Craniofacial and Regenerative Biology, King's College London, London SE1 9RT, UK. Electronic address: eileen.gentleman@kcl.ac.uk.

PMID: 34478627
DOI: 10.1016/j.stem.2021.08.008

Abstract

In this issue of Cell Stem Cell, Tallapragada et al. (2021) present an intestinal organoid culture system for high-throughput live imaging to investigate niche-independent mechanisms of crypt fission. They find that Piezo activity downregulates Lgr5 expression in stretched epithelial cells within inflated organoids, which form multiple new crypts upon collapse.

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MeSH terms

Cell Count
Epithelial Cells*
Organoids*