Male HELLP pups experience sensorimotor delays and reduced body weight

Ashley Griffin; Shauna-Kay Spencer; Teylor Bowles; Lucia Solis; Reanna Robinson; Sumana Ramarao; Kedra Wallace

doi:10.1016/j.physbeh.2021.113567

Male HELLP pups experience sensorimotor delays and reduced body weight

Physiol Behav. 2021 Nov 1:241:113567. doi: 10.1016/j.physbeh.2021.113567. Epub 2021 Aug 30.

Authors

Ashley Griffin¹, Shauna-Kay Spencer², Teylor Bowles², Lucia Solis², Reanna Robinson², Sumana Ramarao³, Kedra Wallace⁴

Affiliations

¹ Program in Neuroscience, 2500 North State Street, University of Mississippi Medical Center, Jackson, MS 39216, United States.
² Department of Obstetrics and Gynecology, 2500 North State Street, University of Mississippi Medical Center, Jackson, MS 39216, United States.
³ Department of Pediatrics, 2500 North State Street, University of Mississippi Medical Center, Jackson, MS 39216, United States.
⁴ Department of Obstetrics and Gynecology, 2500 North State Street, University of Mississippi Medical Center, Jackson, MS 39216, United States; Department of Neurobiology and Anatomical Sciences, 2500 North State Street, University of Mississippi Medical Center, Jackson, MS 39216, United States. Electronic address: kwallace2@umc.edu.

Abstract

Offspring of Preeclampsia (PreE) and HELLP Syndrome are at an increased risk of developing neurodevelopmental disorders. In the current study we sought to determine if offspring from experimental models of PreE and HELLP had evidence of early onset neurodevelopmental delay. Offspring from PreE, HELLP and normal pregnant dams were assessed in a battery of sensorimotor tests beginning on postnatal day (PND) 3. Male HELLP offspring showed altered behavior in the surface righting reflex on PND 3 and cliff avoidance task from PND 3-6 relative to other groups. Results suggest that there are sex differences in offspring born to dams with PreE and HELLP.

Keywords: Behavior; HELLP; Neurodevelopment; Offspring; Preeclampsia; Sensorimotor.

Publication types

Research Support, N.I.H., Extramural

MeSH terms

Body Weight
Female
HELLP Syndrome*
Humans
Male
Pregnancy
Prenatal Exposure Delayed Effects*
Reflex, Righting

Abstract

Publication types

MeSH terms

Grants and funding