Cerebellar injury in premature neonates: Imaging findings and relationship with outcome

Marie Brossard-Racine; Catherine Limperopoulos

doi:10.1016/j.semperi.2021.151470

Cerebellar injury in premature neonates: Imaging findings and relationship with outcome

Semin Perinatol. 2021 Nov;45(7):151470. doi: 10.1016/j.semperi.2021.151470. Epub 2021 Aug 21.

Authors

Marie Brossard-Racine¹, Catherine Limperopoulos²

Affiliations

¹ Advances in Brain and Child Development Research Laboratory, Research Institute of McGill University Health Center - Child Heald and Human Development, Montreal PQ, Canada; School of Physical and Occupational Therapy and Department of Pediatrics, Division of Neonatology, McGill University, Montreal PQ, Canada. Electronic address: marie.brossardracine@mcgill.ca.
² Institute for the Developing Brain; Prenatal Pediatrics Institute; Division of Neonatology; Division of Diagnostic Imaging and Radiology, Children's National Health System, Washington DC, USA.

PMID: 34462245
DOI: 10.1016/j.semperi.2021.151470

Abstract

Cerebellar hemorrhagic injury (CHI) is a common complication of preterm birth. There are now many studies that have investigated the developmental consequences of CHI. This review summarizes the present state of evidence regarding the outcomes of prematurity related CHI, with a particular focus on the neuroimaging characteristics associated with adverse outcomes. Studies published to date suggest that the severity of functional deficits is dependent on injury size and topography. However, the unique contribution of the CHI to outcomes still needs to be further investigated to ensure optimal prognostic counseling.

Keywords: Cerebellar injury; Magnetic resonance imaging; Neurodevelopmental outcome; Prematurity.

Publication types

Review

MeSH terms

Cerebellar Diseases*
Cerebellum
Humans
Infant, Newborn
Infant, Premature
Infant, Premature, Diseases* / diagnostic imaging
Magnetic Resonance Imaging
Premature Birth*