The Family Traveling Salesperson Problem (FTSP) is a variant of the Traveling Salesperson Problem (TSP), in which all vertices are divided into several different families, and the goal of the problem is to find a loop that concatenates a specified number of vertices with minimal loop overhead. As a Non-deterministic Polynomial Complete (NP-complete) problem, it is difficult to deal with it by the traditional computing. On the contrary, as a computer with strong parallel ability, the DNA computer has incomparable advantages over digital computers when dealing with NP problems. Based on this, a DNA algorithm is proposed to deal with FTSP based on the Adleman-Lipton model. In the algorithm, the solution of the problem can be obtained by executing several basic biological manipulations on DNA molecules with O ( N2 ) computing complexity ( N is the number of vertices in the problem without the origin). Through the simulation experiments on some benchmark instances, the results show that the parallel DNA algorithm has better performance than traditional computing. The effectiveness of the algorithm is verified by deducing the algorithm process in detail. Furthermore, the algorithm further proves that DNA computing, as one of the parallel computing methods, has the potential to solve more complex big data problems.