Endoscopic ultrasound (EUS)-guided cylindrical interstitial laser ablation (CILA) on in vivo porcine pancreas

Van Gia Truong; Seok Jeong; Jin-Seok Park; Van Nam Tran; Sung Min Kim; Don Haeng Lee; Hyun Wook Kang

doi:10.1364/BOE.427379

Endoscopic ultrasound (EUS)-guided cylindrical interstitial laser ablation (CILA) on in vivo porcine pancreas

Biomed Opt Express. 2021 Jun 24;12(7):4423-4437. doi: 10.1364/BOE.427379. eCollection 2021 Jul 1.

Authors

Van Gia Truong^{1

2}, Seok Jeong^{3

2}, Jin-Seok Park³, Van Nam Tran¹, Sung Min Kim⁴, Don Haeng Lee³, Hyun Wook Kang^{1

5}

Affiliations

¹ Industry 4.0 Convergence Bionics Engineering, Pukyong National University, Busan, Republic of Korea.
² These authors contributed equally to this work.
³ Department of Internal Medicine, Inha University School of Medicine, and the National Center of Efficacy Evaluation for the Development of Health Products Targeting Digestive Disorders, Inha University Hospital, Incheon, Republic of Korea.
⁴ Bluecore Company, Inc., Busan, Republic of Korea.
⁵ Department of Biomedical Engineering, Pukyong National University, Busan, Republic of Korea.

Abstract

This study aims to demonstrate the feasibility of cylindrical interstitial laser ablation (CILA) in porcine pancreatic tissue to develop a EUS-guided PC ablation technique with enhanced safety. A diffusing applicator created a uniformly symmetrical laser ablation in pancreatic tissue. Ex vivo tests presented that both ablation thickness and volume increased linearly with the applied power (R² = 0.96 and 0.90, respectively) without carbonization and fiber degradation. The numerical simulations matched well with the experimental results in terms of temperature development and thermal damage (deviation of ≤ 15%). In vivo tests with EUS confirmed easy insertion and high durability of the diffusing applicator. EUS-guided CILA warranted a feasible therapeutic capacity of ablating in vivo pancreatic tissue. The proposed EUS-guided CILA can be a feasible therapeutic approach to treat PC with predictable thermal ablation and enhanced safety.