Molecular mechanisms of lidocaine

Resiana Karnina; Syafri Kamsul Arif; Mochammad Hatta; Agussalim Bukhari

doi:10.1016/j.amsu.2021.102733

Molecular mechanisms of lidocaine

Ann Med Surg (Lond). 2021 Aug 17:69:102733. doi: 10.1016/j.amsu.2021.102733. eCollection 2021 Sep.

Authors

Resiana Karnina^{1

2}, Syafri Kamsul Arif³, Mochammad Hatta⁴, Agussalim Bukhari⁵

Affiliations

¹ Doctoral Program of Biomedical Sciences, Faculty of Medicine, Hasanuddin University, Makassar, Sulawesi Selatan, Indonesia.
² Faculty of Medicine, Muhammadiyah University of Jakarta, Banten, Indonesia.
³ Department of Anesthesiology, Faculty of Medicine, Hasanuddin University, Sulawesi Selatan, Indonesia.
⁴ Department of Microbiology, Faculty of Medicine, Hasanuddin University, Makassar, Sulawesi Selatan, Indonesia.
⁵ Department of Nutritional Sciences, Faculty of Medicine, Hasanuddin University, Sulawesi Selatan, Indonesia.

Abstract

Lidocaine is an amide-class local anesthetic used clinically to inhibit pain sensations. Systemic administration of lidocaine has antinociceptive, antiarrhythmic, anti-inflammatory, and antithrombotic effects. Lidocaine exerts these effects under both acute and chronic pain conditions and acute respiratory distress syndrome through mechanisms that can be independent of its primary mechanism of action, sodium channel inhibition. Here we review the pathophysiological underpinnings of lidocaine's role as an anti-nociceptive, anti-inflammatory mediated by toll-like receptor (TLR) and nuclear factor kappa-β (NF-kβ) signalling pathways and downstream cytokine effectors high mobility group box 1 (HMGB1) and tumour necrosis factor-α (TNF-α).

Keywords: Analgesia; Inflammation; Lidocaine; Local anesthesia; Neurotransmitter; Pain.

Publication types

Review