SIRT1 Activation Enhancing 8,3'-Neolignans from the Twigs of Corylopsis coreana Uyeki

Hyun-Woo Kim; Jin-Bum Jeon; Mi Zhang; Hyo-Moon Cho; Byeol Ryu; Ba-Wool Lee; William H Gerwick; Won-Keun Oh

doi:10.3390/plants10081684

SIRT1 Activation Enhancing 8,3'-Neolignans from the Twigs of Corylopsis coreana Uyeki

Plants (Basel). 2021 Aug 16;10(8):1684. doi: 10.3390/plants10081684.

Authors

Hyun-Woo Kim^{1

2}, Jin-Bum Jeon¹, Mi Zhang¹, Hyo-Moon Cho¹, Byeol Ryu¹, Ba-Wool Lee¹, William H Gerwick^{2

3}, Won-Keun Oh¹

Affiliations

¹ Korea Bioactive Natural Material Bank, Research Institute of Pharmaceutical Sciences, College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul 08826, Korea.
² Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California, La Jolla, CA 92093, USA.
³ Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA 92093, USA.

Abstract

Three undescribed 8,3'-neolignans, corynol (1), 3-methoxy-corynol (2) and 3'-deoxy-corynol (3), together with two bergenin derivatives, three flavonoids, two hydrolysable tannins and six simple phenolic compounds, were isolated from the twigs of Corylopsis coreana Uyeki. The structures of the 8,3'-neolignans were elucidated by analyzing their NMR, HRESIMS and ECD spectra. All the isolated compounds were evaluated for their SIRT1 stimulatory activity, and 3'-deoxy-corynol (3) showed SIRT1 stimulation activity. Furthermore, a docking study of 3 was performed with three representative binding pockets of SIRT1.

Keywords: Corylopsis coreana; SIRT1; hamamelidacease; neolignan.

Abstract

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