Hybrid Hosts Based on Sodium Alginate and Porous Clay Heterostructures for Drug Encapsulation

Anda Ionelia Voicu Mihai; Sorina Alexandra Gȃrea; Eugeniu Vasile; Adi Ghebaur; Horia Iovu

doi:10.3390/polym13162803

Hybrid Hosts Based on Sodium Alginate and Porous Clay Heterostructures for Drug Encapsulation

Polymers (Basel). 2021 Aug 20;13(16):2803. doi: 10.3390/polym13162803.

Authors

Anda Ionelia Voicu Mihai^{1

2}, Sorina Alexandra Gȃrea^{1

2}, Eugeniu Vasile³, Adi Ghebaur^{1

2}, Horia Iovu^{1

2

4}

Affiliations

¹ Faculty of Applied Chemistry and Materials Science, University Politehnica of Bucharest, 1-7 Gh. Polizu Street, 011061 Bucharest, Romania.
² Advanced Polymer Materials Group, University Politehnica of Bucharest, 1-7 Gh. Polizu Street, 011061 Bucharest, Romania.
³ Department of Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Applied Chemistry and Material Science, University Politehnica of Bucharest, 1-7 Polizu, 011061 Bucharest, Romania.
⁴ Academy of Romanian Scientists, 54 Splaiul Independentei, 050094 Bucharest, Romania.

Abstract

In this study, some hybrid materials based on sodium alginate (NaAlg) and porous clay heterostructures (PCHs) were investigated as new hosts for 5-Fluorouracil (5-FU) encapsulation. The hybrid hosts were prepared by ionotropic gelation technique using different concentrations of PCHs (1, 3, and 10 wt%) in order to identify the optimal parameters for encapsulation and drug release. The obtained hybrid materials were characterized using FTIR Spectrometry, thermogravimetric analysis (TGA), scanning electron microscopy (SEM), and UV-Vis spectrometry to investigate the interactions of the raw materials involved in the preparation of hybrid hosts, the influence of PCHs concentrations on drug encapsulation efficiency and drug release profile. All the results show that the synthesized hybrid materials were able to load a high amount of 5-FU, the encapsulation efficiency and the release profile being influenced by the concentrations of PCHs.

Keywords: 5-Fluorouracil; drug; hybrids; porous clay heterostructures; sodium alginate.