Polyenvironmental and polygenic risk scores and the emergence of psychotic experiences in adolescents

Gabrielle de Oliveira S V Navarro; Laís Fonseca; Fernanda Talarico; Letícia Spíndola; Marcos L Santoro; Vanessa K Ota; Hugo Cogo-Moreira; Jair Mari; Luis A Rohde; Eurípedes C Miguel; Rodrigo A Bressan; Pedro M Pan; Ary Gadelha; Sintia I Belangero

doi:10.1016/j.jpsychires.2021.07.057

Polyenvironmental and polygenic risk scores and the emergence of psychotic experiences in adolescents

J Psychiatr Res. 2021 Oct:142:384-388. doi: 10.1016/j.jpsychires.2021.07.057. Epub 2021 Aug 6.

Affiliations

¹ Laboratory of Integrative Neuroscience (LiNC), Department of Psychiatry, Federal University of São Paulo, São Paulo, Brazil. Electronic address: gabi.onavarro@gmail.com.
² Laboratory of Integrative Neuroscience (LiNC), Department of Psychiatry, Federal University of São Paulo, São Paulo, Brazil.
³ Department of Psychiatry, University of Alberta, Alberta, Canada.
⁴ Department of Clinical Science, NORMENT, KG Jebsen Centre for Psychosis Research, University of Bergen, Bergen, Norway; Dr Einar Martens Research Group for Biological Psychiatry, Centre for Medical Genetics and Molecular Medicine, Haukeland University Hospital, Bergen, Norway.
⁵ Genetics Division, Department of Morphology and Genetics, Federal University of São Paulo, São Paulo, Brazil.
⁶ Department of Education, ICT and Learning, Østfold University College, Halden, Norway.
⁷ ADHD and Developmental Psychiatry Programs, Hospital de Clínicas de Porto Alegre, Federal University of Rio Grande do Sul, Brazil.
⁸ Department of Psychiatry, Faculty of Medicine, University of São Paulo, São Paulo, Brazil.
⁹ Laboratory of Integrative Neuroscience (LiNC), Department of Psychiatry, Federal University of São Paulo, São Paulo, Brazil; Genetics Division, Department of Morphology and Genetics, Federal University of São Paulo, São Paulo, Brazil. Electronic address: sinbelangero@gmail.com.

PMID: 34450553
DOI: 10.1016/j.jpsychires.2021.07.057

Abstract

Psychotic experiences (PE) are forms of hallucinations and delusions neither reaching the intensity and functional impairment required to be regarded as full psychotic symptoms nor a psychotic disorder. Here we investigated the ability to predict PE using multiple models (regressions, mediation and moderation) using polygenic risk score for psychotic experiences (PE-PRS), polygenic risk score for schizophrenia (SCZ-PRS), and polyenvironmental risk score (PERS) in youth from a Brazilian sample. The scores were not able to predict outcome, either when both scores were combined (PERS + PE-PRS and PERS + SCZ-PRS) or separately. Our results show that there is no association between PE and PRS or PERS among adolescents in our Brazilian sample. The lack of association may be a result of the absence of better representativeness regarding genetic and environmental factors of our population.

Keywords: Environmental; PERS; PRS; Polyenvironmental risk score; Polygenic risk score; Psychotic experiences.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adolescent
Genetic Predisposition to Disease
Hallucinations
Humans
Multifactorial Inheritance / genetics
Psychotic Disorders* / epidemiology
Psychotic Disorders* / genetics
Risk Factors
Schizophrenia* / epidemiology
Schizophrenia* / genetics