Prognostic utility of the IgM oligoclonal bands against myelin lipids in multiple sclerosis

J Neuroimmunol. 2021 Oct 15:359:577698. doi: 10.1016/j.jneuroim.2021.577698. Epub 2021 Aug 21.

Abstract

IgM oligoclonal bands (OCMBs) against myelin-specific lipids have been identified as a marker for poor prognosis in multiple sclerosis (MS). The aim is to examine the relation between lipid-specific OCMBs (LS-OCMBs) and the evolution of MS. An analytical, ambispective and individual-based study was conducted. We selected 116 patients, out of whom 95 had LS-OCMBs. The predominant lipid recognized was phosphatidylcholine. The positive gangliosides OCMB group reached better scores in the 9HPT, and the phosphatidylcholine, sphingolipids and phosphatidylethanolamine OCMB groups showed statistical differences in the magnetic resonance parameters. In conclusion: some LS-OCMBs showed statistically significant differences with functional or imaging tests.

Keywords: Biomarkers; Demyelinating diseases; Multiple sclerosis; Myelin-specific lipids; Neuroimmunology; Oligoclonal bands.

Publication types

  • Observational Study

MeSH terms

  • Cross-Sectional Studies
  • Female
  • Humans
  • Immunoglobulin M / cerebrospinal fluid*
  • Immunoglobulin M / immunology
  • Lipids / cerebrospinal fluid*
  • Lipids / immunology
  • Magnetic Resonance Imaging / methods
  • Male
  • Multiple Sclerosis / cerebrospinal fluid*
  • Multiple Sclerosis / diagnostic imaging*
  • Multiple Sclerosis / immunology
  • Myelin Sheath / immunology
  • Oligoclonal Bands / cerebrospinal fluid*
  • Oligoclonal Bands / immunology
  • Prognosis

Substances

  • Immunoglobulin M
  • Lipids
  • Oligoclonal Bands