Comparative degradation of 5-fluorouracil in aqueous solution by using H2O2-modified subcritical water, photocatalytic oxidation and electro-Fenton processes

Abstract

This study investigated the degradation of the antineoplastic agent 5-fluorouracil (5-FU) widely applied to treat different cancers using different advanced oxidation processes such as electro-Fenton (EF), photocatalysis with TiO_2, and H₂O₂-modified subcritical water oxidation. The treatment with the EF process was the most efficient compared to others. Interestingly, in the EF process, the oxidative degradation of 5-FU behaved differently depending on the anode used. At low currents (20 and 40 mA), Pt and DSA anodes performed better than BDD and Ti₄O₇ anodes. In contrast, at the higher current of 120 mA, the production of heterogeneous hydroxyl radicals (M(^•OH)) became important and contributed significantly to the oxidation of 5-FU in addition to homogeneous ^•OH generated in the bulk solution. These latter have high O₂-evolution overpotential leading to the high amount of physisorbed M(^•OH) compared to Pt and DSA. The oxidative degradation of 5-FU was then performed by titanium dioxide-based photocatalytic oxidation and subcritical water oxidation processes, both of which showed a lower degradation efficiency and failed to achieve complete mineralization. Finally, a comparison was performed in laboratory-scale, taking into account the following performance indicators: the degradation efficiency, the mineralization power, the cost of equipment and reagents, and the energy required for the treatment of 5-FU.

Keywords: 5-Fluorouracil; Electro-Fenton; Photocatalysis; Subcritical water; Wastewater treatment.