The cAMP responsive element modulator (CREM) is a regulator of CD4+ T cell function

Sudheendra Hebbar Subramanyam; Klaus Tenbrock

doi:10.1515/hsz-2021-0249

The cAMP responsive element modulator (CREM) is a regulator of CD4⁺ T cell function

Biol Chem. 2021 Aug 26;402(12):1591-1596. doi: 10.1515/hsz-2021-0249. Print 2021 Nov 25.

Authors

Sudheendra Hebbar Subramanyam¹, Klaus Tenbrock^{1

2

3}

Affiliations

¹ Department of Pediatrics, Pediatric Pneumology, Allergology and Immunology, RWTH Aachen University, Aachen, Germany.
² Interdisciplinary Center for Clinical Research IZKF, Aachen, Germany.
³ Interdisciplinary Center for Clinical Research IZKF, Münster, Germany.

PMID: 34448385
DOI: 10.1515/hsz-2021-0249

Abstract

The cAMP responsive element modulator (CREM) is a transcriptional regulator of different effector cytokines in CD4⁺ T cells including IL-2, IL-17, IL-21 but also IL-4 and IL-13 and thus an important determinant of central T helper cell functions. Our review gives an overview over the regulation of CREM in T cells and the pleiotropic effects of CREM on CD4⁺ T cells in health and autoimmune diseases with a particular focus on systemic lupus erythematosus.

Keywords: CREMα; ICER; Th17; cAMP; interleukin 2; metabolism.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Cyclic AMP Response Element Modulator*
Humans
Interleukin-17*
Lupus Erythematosus, Systemic
T-Lymphocytes, Regulatory

Substances

Interleukin-17
Cyclic AMP Response Element Modulator