Inflammation and Aging of Hematopoietic Stem Cells in Their Niche

Daozheng Yang; Gerald de Haan

doi:10.3390/cells10081849

Inflammation and Aging of Hematopoietic Stem Cells in Their Niche

Cells. 2021 Jul 21;10(8):1849. doi: 10.3390/cells10081849.

Authors

Daozheng Yang¹, Gerald de Haan^{1

2}

Affiliations

¹ European Research Institute for the Biology of Ageing (ERIBA), University Medical Center Groningen, University of Groningen, 9713 AV Groningen, The Netherlands.
² Sanquin Research, Landsteiner Laboratory, Amsterdam UMC, 1006 AD Amsterdam, The Netherlands.

Abstract

Hematopoietic stem cells (HSCs) sustain the lifelong production of all blood cell lineages. The functioning of aged HSCs is impaired, including a declined repopulation capacity and myeloid and platelet-restricted differentiation. Both cell-intrinsic and microenvironmental extrinsic factors contribute to HSC aging. Recent studies highlight the emerging role of inflammation in contributing to HSC aging. In this review, we summarize the recent finding of age-associated changes of HSCs and the bone marrow niche in which they lodge, and discuss how inflammation may drive HSC aging.

Keywords: aging; hematopoietic stem cells; heterogeneity; inflammation; niche.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Cell Proliferation
Cell Self Renewal
Cellular Senescence*
Hematopoietic Stem Cells / metabolism
Hematopoietic Stem Cells / pathology*
Humans
Inflammation / metabolism
Inflammation / pathology*
Inflammation Mediators / metabolism
Phenotype
Signal Transduction
Stem Cell Niche*

Substances

Inflammation Mediators