MiRNAs and Cancer: Key Link in Diagnosis and Therapy

Yu Shi; Zihao Liu; Qun Lin; Qing Luo; Yinghuan Cen; Juanmei Li; Xiaolin Fang; Chang Gong

doi:10.3390/genes12081289

MiRNAs and Cancer: Key Link in Diagnosis and Therapy

Genes (Basel). 2021 Aug 23;12(8):1289. doi: 10.3390/genes12081289.

Authors

Yu Shi^{1

2}, Zihao Liu^{1

2}, Qun Lin^{1

2}, Qing Luo^{1

2}, Yinghuan Cen^{1

2}, Juanmei Li^{1

2}, Xiaolin Fang^{1

2}, Chang Gong^{1

2}

Affiliations

¹ Breast Tumor Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou 510000, China.
² Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou 510120, China.

Abstract

Since the discovery of the first microRNA (miRNA), the exploration of miRNA biology has come to a new era in recent decades. Monumental studies have proven that miRNAs can be dysregulated in different types of cancers and the roles of miRNAs turn out to function to either tumor promoters or tumor suppressors. The interplay between miRNAs and the development of cancers has grabbed attention of miRNAs as novel tools and targets for therapeutic attempts. Moreover, the development of miRNA delivery system accelerates miRNA preclinical implications. In this review, we depict recent advances of miRNAs in cancer and discuss the potential diagnostic or therapeutic approaches of miRNAs.

Keywords: cancer; diagnosis; microRNA; therapy.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Gene Expression Regulation, Neoplastic / genetics
Genetic Therapy / trends*
Humans
MicroRNAs / genetics*
MicroRNAs / therapeutic use
Neoplasms / diagnosis
Neoplasms / genetics*
Neoplasms / pathology
Neoplasms / therapy

Substances

MicroRNAs