Sequential therapy with combined trans-papillary endoscopic naso-pancreatic and endoscopic retrograde pancreatic drainage for pancreatic pseudocysts

Yong-Gang He; Jing Li; Xue-Hui Peng; Jing Wu; Ming-Xun Xie; Yi-Chen Tang; Lu Zheng; Xiao-Bing Huang

doi:10.12998/wjcc.v9.i22.6254

Sequential therapy with combined trans-papillary endoscopic naso-pancreatic and endoscopic retrograde pancreatic drainage for pancreatic pseudocysts

World J Clin Cases. 2021 Aug 6;9(22):6254-6267. doi: 10.12998/wjcc.v9.i22.6254.

Authors

Yong-Gang He¹, Jing Li¹, Xue-Hui Peng¹, Jing Wu¹, Ming-Xun Xie², Yi-Chen Tang¹, Lu Zheng¹, Xiao-Bing Huang³

Affiliations

¹ Department of Hepatobiliary Surgery, The Second Affiliated Hospital of Army Medical University, Chongqing 400037, China.
² Department of Radiology, The Second Affiliated Hospital of Army Medical University, Chongqing 400037, China.
³ Department of Hepatobiliary Surgery, The Second Affiliated Hospital of Army Medical University, Chongqing 400037, China. 1038915320@qq.com.

Abstract

Background: Endoscopic retrograde pancreatic drainage (ERPD) and stent implantation has become the major treatment method for pancreatic pseudocysts. However, it is associated with a high recurrence rate and infection.

Aim: To manage pancreatic pseudocysts by sequential therapy with endoscopic naso-pancreatic drainage (ENPD) combined with ERPD and evaluate the treatment outcome.

Methods: One hundred and sixty-two cases of pancreatic pseudocyst confirmed by endoscopic examination at our hospital between January 2014 and January 2020 were retrospectively analyzed. There were 152 cases of intubation via the duodenal papilla, of which 92 involved pancreatic duct stent implantation and 60 involved sequential therapy with combined ENPD and ERPD (two-step procedure). The success rate of the procedure, incidence of complications (infection, bleeding, etc.), recurrence, and length and cost of hospitalization were compared between the two groups.

Results: The incidence of infection was significantly higher in the ERPD group (12 cases) than in the two-step procedure group (2 cases). Twelve patients developed infection in the ERPD group, and anti-infection therapy was effective in five cases but not in the remaining seven cases. Infection presented as fever and chills in the two-step procedure group. The reoperation rate was significantly higher in the ERPD group with seven cases compared with zero cases in the two-step procedure group (P < 0.05). Similarly, the recurrence rate was significantly higher in the ERPD group (19 cases) than in the two-step procedure group (0 cases).

Conclusion: Sequential therapy with combined ENPD and ERPD is safe and effective in patients with pancreatic pseudocysts.

Keywords: Endoscopic nasobiliary drainage; Endoscopic retrograde cholangiopancreatography; Endoscopic retrograde pancreatic drainage; Endoscopic ultrasonography trans-gastric puncture drainage of the pancreas; Endoscopy; Pancreatic pseudocyst.