Effect of erythropoietin administration on the expression of brain-derived neurotrophic factor, stromal cell-derived Factor-1, and neuron-specific enolase in traumatic brain injury: A literature review

Muhammad Fadli Said; Andi Asadul Islam; Muhammad Nasrum Massi; Prihantono

doi:10.1016/j.amsu.2021.102666

Effect of erythropoietin administration on the expression of brain-derived neurotrophic factor, stromal cell-derived Factor-1, and neuron-specific enolase in traumatic brain injury: A literature review

Ann Med Surg (Lond). 2021 Aug 5:69:102666. doi: 10.1016/j.amsu.2021.102666. eCollection 2021 Sep.

Authors

Muhammad Fadli Said¹, Andi Asadul Islam¹, Muhammad Nasrum Massi², Prihantono³

Affiliations

¹ Department of Neurosurgery, Faculty of Medicine, Hasanuddin University, Makassar, South Sulawesi, Indonesia.
² Departement of Microbiology, Faculty of Medicine, Hasanuddin University, Makassar, South Sulawesi, Indonesia.
³ Department of Surgery, Faculty of Medicine, Hasanuddin University, Makassar, South Sulawesi, Indonesia.

Abstract

Traumatic brain injury (TBI) is a major cause of death and lifelong disability around the world that predominantly affects young and middle-aged people. Erythropoietin (EPO) is a promising therapeutic agent for a variety of neurological injuries including TBI due to its neuroprotective effects. Here we review the impact of exogenous erythropoietin administration on the expression of brain-derived neurotrophic factor (BDNF), stromal cell-derived factor-1 (SDF-1), and neuron-specific enolase (NSE) levels in cerebrospinal fluid after TBI as biomarkers for neuron regeneration and survival to predict TBI outcome.

Keywords: BDNF; Erythropoietin; NSE; Neuroprotection; SDF-1; Traumatic brain injury.

Publication types

Review