Epigenetic Age Acceleration Reflects Long-Term Cardiovascular Health

Circ Res. 2021 Oct;129(8):770-781. doi: 10.1161/CIRCRESAHA.121.318965. Epub 2021 Aug 25.

Brian T Joyce^{1

2}, Tao Gao^{1

2}, Yinan Zheng^{1

2}, Jiantao Ma^{3

4}, Shih-Jen Hwang^{3

4}, Lei Liu⁵, Drew Nannini^{1

2}, Steve Horvath⁶, Ake T Lu⁶, Norrina Bai Allen², David R Jacobs Jr⁷, Myron Gross⁷, Amy Krefman², Hongyan Ning², Kiang Liu², Cora E Lewis⁸, Pamela J Schreiner⁹, Stephen Sidney¹⁰, James M Shikany⁸, Daniel Levy^{3

4}, Philip Greenland², Lifang Hou^#^{1

2}, Donald Lloyd-Jones^#²

¹ Center for Global Oncology, Institute for Global Health (B.T.J., T.G., Y.Z., D.N., L.H.), Feinberg School of Medicine, Northwestern University, Chicago, IL.
² Department of Preventive Medicine (B.T.J., T.G., Y.Z., D.N., N.B.A., A.K., H.N., K.L., P.G., L.H., D.L.-J.), Feinberg School of Medicine, Northwestern University, Chicago, IL.
³ The Framingham Heart Study, Framingham, MA; (J.M., S.-J.H., D.L.).
⁴ Population Sciences Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD (J.M., S.-J.H., D.L.).
⁵ Division of Biostatistics, Washington University, St. Louis, MO (L.L.).
⁶ Department of Human Genetics, UCLA David Geffen School of Medicine, Los Angeles, CA (S.H., A.T.L.).
⁷ Division of Epidemiology and Community Health, School of Public Health (D.R.J., M.G.), University of Minnesota, Minneapolis.
⁸ Division of Preventive Medicine, School of Medicine, University of Alabama at Birmingham (C.E.L., J.M.S.).
⁹ School of Public Health (P.J.S.), University of Minnesota, Minneapolis.
¹⁰ Division of Research, Kaiser Permanente, Oakland, CA (S.S.).

^# Contributed equally.

Abstract

[Figure: see text].

Keywords: DNA methylation; blood pressure; cardiovascular diseases; humans; young adult.