Salivary gland: A budding genius

Oscar Cazares; Ameera S Haque; Ophir D Klein

doi:10.1016/j.devcel.2021.08.001

Salivary gland: A budding genius

Dev Cell. 2021 Aug 23;56(16):2271-2272. doi: 10.1016/j.devcel.2021.08.001.

Authors

Oscar Cazares¹, Ameera S Haque¹, Ophir D Klein²

Affiliations

¹ Program in Craniofacial Biology and Division of Craniofacial Anomalies, Department of Orofacial Sciences, University of California San Francisco, San Francisco, CA, USA.
² Program in Craniofacial Biology and Division of Craniofacial Anomalies, Department of Orofacial Sciences, University of California San Francisco, San Francisco, CA, USA; Division of Medical Genetics, Department of Pediatrics and Institute for Human Genetics, University of California San Francisco, San Francisco, CA, USA. Electronic address: ophir.klein@ucsf.edu.

PMID: 34428396
DOI: 10.1016/j.devcel.2021.08.001

Abstract

During salivary gland development, branches arise through formation of new end buds (budding) and division of existing buds (clefting). In a recent Cell study, Wang et al., (2021) report that mouse salivary gland budding is reliant on a delicate interplay between epithelial cells and the extracellular matrix surrounding them.

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MeSH terms

Animals
Cell Division
Epithelial Cells*
Extracellular Matrix
Mice
Salivary Glands*