A retrospective comparison of outcomes for open vs. laparoscopic surgical techniques in pediatric ulcerative colitis

Brent A Willobee; Jennifer A Nguyen; Anthony Ferrantella; Hallie J Quiroz; Anthony R Hogan; Ann-Christina Brady; Samir Pandya; Amber H Langshaw; Juan E Sola; Chad M Thorson; Eduardo A Perez

doi:10.21037/tgh-20-189

A retrospective comparison of outcomes for open vs. laparoscopic surgical techniques in pediatric ulcerative colitis

Transl Gastroenterol Hepatol. 2021 Jul 25:6:41. doi: 10.21037/tgh-20-189. eCollection 2021.

Affiliations

¹ Daughtry Family Department of Surgery, University of Miami Miller School of Medicine, Miami, FL, USA.
² Department of Surgery, UT Southwestern Medical Center, Dallas, TX USA.
³ Department of Pediatrics, University of Miami Miller School of Medicine, Miami, FL, USA.

Abstract

Background: Ulcerative colitis (UC) is an aggressive disease in the pediatric population and a cause of significant, lifelong morbidity. The aim of this study is to compare surgical complications in pediatric patients undergoing laparoscopic vs. open surgical treatment for UC.

Methods: We queried the Kids' Inpatient Database (KID) for all cases of UC undergoing surgical treatment in 2009 and 2012. We identified patients who received total colectomy without proctectomy (n=413) or total proctocolectomy (n=196) and performed univariate and multivariate analyses comparing laparoscopic vs. open procedures.

Results: In pediatric UC patients undergoing total colectomy without proctectomy, open procedures were associated with more complications than laparoscopic, including fluid and electrolyte disorders (40% vs. 28%), surgical wound dehiscence (6% vs. 2%), septicemia (18% vs. 2%), and gastrointestinal disorders (16% vs. 7%) among others, all P<0.05. Likewise, in patients with UC undergoing total proctocolectomy, there were more complications in open vs. laparoscopic technique, including increased transfusion requirements (25% vs. 7%, P=0.001) and significantly more gastrointestinal upset, including nausea, vomiting, and diarrhea (11% vs. 1%, P=0.003). In multivariate analysis, patients who underwent total colectomy with or without proctectomy had an increased risk of experiencing any complication when their procedure was performed in an open or non-elective fashion (all odds ratio >2.4; all P<0.001).

Conclusions: The laparoscopic approach was associated with significantly lower rates of surgical complications in pediatric patients undergoing total colectomy with or without proctectomy for UC. These findings demonstrate that laparoscopic technique compares favorably, and may be preferable, to the open approach in selected pediatric patients with UC.

Keywords: Laparoscopic; inflammatory bowel disease (IBD); minimally invasive; minimally invasive surgery (MIS); outcomes; pediatric surgery; ulcerative colitis (UC).