Regulatory Non-coding RNAs for Death Associated Protein Kinase Family

Qingshui Wang; Youyu Lin; Wenting Zhong; Yu Jiang; Yao Lin

doi:10.3389/fmolb.2021.649100

Regulatory Non-coding RNAs for Death Associated Protein Kinase Family

Front Mol Biosci. 2021 Aug 6:8:649100. doi: 10.3389/fmolb.2021.649100. eCollection 2021.

Authors

Qingshui Wang^{1

2}, Youyu Lin², Wenting Zhong², Yu Jiang³, Yao Lin^{1

2}

Affiliations

¹ Central Laboratory at the Second Affiliated Hospital of Fujian Traditional Chinese Medical University, Collaborative Innovation Center for Rehabilitation Technology, Fujian University of Traditional Chinese Medicine, Fuzhou, China.
² Key Laboratory of Optoelectronic Science and Technology for Medicine of Ministry of Education, College of Life Sciences, Fujian Normal University, Fuzhou, China.
³ Prenatal Diagnosis Centre, Women and Children's Hospital, School of Medicine, Xiamen University, Xiamen, China.

Abstract

The death associated protein kinases (DAPKs) are a family of calcium dependent serine/threonine kinases initially identified in the regulation of apoptosis. Previous studies showed that DAPK family members, including DAPK1, DAPK2 and DAPK3 play a crucial regulatory role in malignant tumor development, in terms of cell apoptosis, proliferation, invasion and metastasis. Accumulating evidence has demonstrated that non-coding RNAs, including microRNA (miRNA), long non-coding RNA (lncRNA) and circRNA, are involved in the regulation of gene expression and tumorigenesis. Recent studies indicated that non-coding RNAs participate in the regulation of DAPKs. In this review, we summarized the current knowledge of non-coding RNAs, as well as the potential miRNAs, lncRNAs and circRNAs, that are involved in the regulation of DAPKs.

Keywords: DAPK; circRNA; lncRNA; miRNA; non-coding RNA.

Publication types

Review