Immune Microenvironment Change and Involvement of Circular RNAs in TIL Cells of Recurrent Nasopharyngeal Carcinoma

Yumin Wang; Zhouying Peng; Yaxuan Wang; Yi Yang; Ruohao Fan; Kelei Gao; Hua Zhang; Zhihai Xie; Weihong Jiang

doi:10.3389/fcell.2021.722224

Immune Microenvironment Change and Involvement of Circular RNAs in TIL Cells of Recurrent Nasopharyngeal Carcinoma

Front Cell Dev Biol. 2021 Aug 6:9:722224. doi: 10.3389/fcell.2021.722224. eCollection 2021.

Authors

Yumin Wang¹, Zhouying Peng¹, Yaxuan Wang¹, Yi Yang², Ruohao Fan¹, Kelei Gao¹, Hua Zhang¹, Zhihai Xie¹, Weihong Jiang¹

Affiliations

¹ Department of Otolaryngology Head and Neck Surgery, Xiangya Hospital, Central South University, Changsha, China.
² Department of Nuclear Medicine, Xiangya Hospital, Central South University, Changsha, China.

Abstract

Nasopharyngeal carcinoma is a malignant tumor that is highly prevalent in southern China and the Southeast Asian belt. Recent studies have shown that the T cells play important regulatory roles in tumorigenesis and progression. We test TIL cell of recurrent nasopharyngeal carcinoma and primary nasopharyngeal carcinoma cell. We found that T cell change in recurrent nasopharyngeal carcinoma and primary nasopharyngeal carcinoma cell. Based on GEO database, we selected differently expressed circRNAs in nasopharyngeal carcinoma tissues. qRTPCR show that some circRNAs also highly expressed in TIL cells. In conclusion, immune microenvironment changed in recurrent nasopharyngeal carcinoma. There is involvement of circular RNAs in this progress, with should be researched further.

Keywords: TIL; circRNA; immune microenvironment; non-coding RNA; recurrent nasopharyngeal carcinoma.