Nanobiotechnology-assisted therapies to manage brain cancer in personalized manner

Monika Nehra; U T Uthappa; Virendra Kumar; Rajesh Kumar; Chandra Dixit; Neeraj Dilbaghi; Yogendra Kumar Mishra; Sandeep Kumar; Ajeet Kaushik

doi:10.1016/j.jconrel.2021.08.027

Nanobiotechnology-assisted therapies to manage brain cancer in personalized manner

J Control Release. 2021 Oct 10:338:224-243. doi: 10.1016/j.jconrel.2021.08.027. Epub 2021 Aug 18.

Authors

Monika Nehra¹, U T Uthappa², Virendra Kumar³, Rajesh Kumar⁴, Chandra Dixit⁵, Neeraj Dilbaghi³, Yogendra Kumar Mishra⁶, Sandeep Kumar⁷, Ajeet Kaushik⁸

Affiliations

¹ Department of Bio and Nano Technology, Guru Jambheshwar University of Science and Technology, Hisar, Haryana 125001, India; Department of Mechanical Engineering, University Institute of Engineering and Technology, Panjab University, Chandigarh 160014, India.
² Department of Environment and Energy Engineering, Chonnam National University, 77 Yongbong-ro, Buk-gu, Gwangju 61186, Republic of Korea; Centre for Nano and Material Sciences, Jain University, Jain Global Campus, Bengaluru 562112, Karnataka, India.
³ Department of Bio and Nano Technology, Guru Jambheshwar University of Science and Technology, Hisar, Haryana 125001, India.
⁴ Department of Mechanical Engineering, University Institute of Engineering and Technology, Panjab University, Chandigarh 160014, India.
⁵ Department of Chemistry, University of Connecticut, Storrs, CT, USA.
⁶ Smart Materials, NanoSYD, Mads Clausen Institute, University of Southern Denmark, Alsion 2, 6400, Sønderborg, Denmark.
⁷ Department of Bio and Nano Technology, Guru Jambheshwar University of Science and Technology, Hisar, Haryana 125001, India. Electronic address: ksandeep36@yahoo.com.
⁸ NanoBioTech Laboratory, Health Systems Engineering, Department of Environmental Engineering, Florida Polytechnic University, Lakeland, FL 33805-8531, United States. Electronic address: akaushik@floridapoly.edu.

PMID: 34418523
DOI: 10.1016/j.jconrel.2021.08.027

Abstract

There are numerous investigated factors that limit brain cancer treatment efficacy such as ability of prescribed therapy to cross the blood-brain barrier (BBB), tumor specific delivery of a therapeutics, transport within brain interstitium, and resistance of tumor cells against therapies. Recent breakthroughs in the field of nano-biotechnology associated with developing multifunctional nano-theranostic emerged as an effective way to manage brain cancer in terms of higher efficacy and least possible adverse effects. Keeping challenges and state-of-art accomplishments into consideration, this review proposes a comprehensive, careful, and critical discussion focused on efficient nano-enabled platforms including nanocarriers for drug delivery across the BBB and nano-assisted therapies (e.g., nano-immunotherapy, nano-stem cell therapy, and nano-gene therapy) investigated for brain cancer treatment. Besides therapeutic efficacy point-of-view, efforts are being made to explore ways projected to tune such developed nano-therapeutic for treating patients in personalized manner via controlling size, drug loading, delivery, and retention. Personalized brain tumor management based on advanced nano-therapies can potentially lead to excellent therapeutic benefits based on unique genetic signatures in patients and their individual disease profile. Moreover, applicability of nano-systems as stimulants to manage the brain cancer growth factors has also been discussed in photodynamic therapy and radiotherapy. Overall, this review offers a comprehensive information on emerging opportunities in nanotechnology for advancing the brain cancer treatment.

Keywords: Brain cancer; Drug delivery to CNS; Nano-biotechnology; Nano-therapeutics; Nanomedicine; Personalized nano-therapy.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Blood-Brain Barrier
Brain
Brain Neoplasms* / drug therapy
Drug Delivery Systems*
Humans
Nanomedicine
Nanotechnology