Dermatologic conditions in Down syndrome

Chenin Ryan; Kishore Vellody; Leah Belazarian; Jillian F Rork

doi:10.1111/pde.14731

Dermatologic conditions in Down syndrome

Pediatr Dermatol. 2021 Nov:38 Suppl 2:49-57. doi: 10.1111/pde.14731. Epub 2021 Aug 21.

Authors

Chenin Ryan¹, Kishore Vellody², Leah Belazarian³, Jillian F Rork^{1

4}

Affiliations

¹ Dartmouth Geisel School of Medicine, Hanover, New Hampshire, USA.
² Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
³ Departments of Pediatrics and Dermatology, University of Massachusetts Medical School, Worcester, Massachusetts, USA.
⁴ Department of Dermatology, Dartmouth-Hitchcock Medical Center, Manchester, New Hampshire, USA.

PMID: 34418156
DOI: 10.1111/pde.14731

Abstract

Down syndrome (DS) is the most common chromosomal condition and affects many organs including the skin. Dermatologists are an integral part of the DS care team. This is a review of both common and rare dermatologic conditions in DS. We provide practical strategies for a successful dermatology interview and examination. We explore the downstream effects of trisomy of chromosome 21, in particular on the immune system, and how these insights may enhance our pathophysiologic understanding of their cutaneous conditions.

Keywords: Down syndrome; alopecia areata; dermatologic conditions; dermatology; eczema; folliculitis; hidradenitis suppurativa; melanoma; onychomycosis; psoriasis; scabies; seborrheic dermatitis; skin; skin cancer; trisomy 21; xerosis.

Publication types

Review

MeSH terms

Down Syndrome* / complications
Humans
Skin
Skin Diseases* / diagnosis