Heterogeneity of DNA damage incidence and repair in different chromatin contexts

Pedro Ortega; Belén Gómez-González; Andrés Aguilera

doi:10.1016/j.dnarep.2021.103210

Heterogeneity of DNA damage incidence and repair in different chromatin contexts

DNA Repair (Amst). 2021 Nov:107:103210. doi: 10.1016/j.dnarep.2021.103210. Epub 2021 Aug 13.

Authors

Pedro Ortega¹, Belén Gómez-González², Andrés Aguilera¹

Affiliations

¹ Centro Andaluz de Biología Molecular y Medicina Regenerativa CABIMER, Universidad de Sevilla-CSIC-Universidad Pablo de Olavide, Seville, Spain; Departamento de Genética, Facultad de Biología, Universidad de Sevilla, Seville, Spain.
² Centro Andaluz de Biología Molecular y Medicina Regenerativa CABIMER, Universidad de Sevilla-CSIC-Universidad Pablo de Olavide, Seville, Spain; Departamento de Genética, Facultad de Biología, Universidad de Sevilla, Seville, Spain. Electronic address: gomezb@us.es.

PMID: 34416542
DOI: 10.1016/j.dnarep.2021.103210

Abstract

It has been long known that some regions of the genome are more susceptible to damage and mutagenicity than others. Recent advances have determined a critical role of chromatin both in the incidence of damage and in its repair. Thus, chromatin arises as a guardian of the stability of the genome, which is altered in cancer cells. In this review, we focus into the mechanisms by which chromatin influences the occurrence and repair of the most cytotoxic DNA lesions, double-strand breaks, in particular at actively transcribed chromatin or related to DNA replication.

Keywords: Chromatin; DNA damage; DNA repair; Double-strand break; Genome instability.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Chromatin*

Substances

Chromatin