Successful pregnancy and follow-up after in vitro fertilization of a kidney transplant patient with systemic lupus erythematosus, primary biliary cholangitis, and hypothyroidism

JBRA Assist Reprod. 2021 Oct 4;25(4):657-660. doi: 10.5935/1518-0557.20210052.

Abstract

This report describes the case of a female kidney transplant patient with systemic lupus erythematosus, primary biliary cholangitis, and postsurgical hypothyroidism due to Grave's disease who had a healthy newborn after in vitro fertilization (IVF). Cases of successful pregnancy involving women who underwent IVF after kidney transplantation have been reported. Normal and stable renal function, adequate immunosuppressant therapy, and well-managed blood pressure are requirements to be eligible for IVF and pregnancy. Primary biliary cholangitis without cirrhosis does not seem to worsen during pregnancy and IVF must be individualized in patients with systemic lupus erythematosus. There are no similar case reports involving kidney transplant patients or individuals with autoimmune disorders, so the decision to perform IVF had to be individualized in order to avoid complications for the mother and fetus.

Keywords: assisted reproductive technology; autoimmune/rheumatologic; in vitro fertilization; kidney transplantation; prepregnancy counseling.

Publication types

  • Case Reports

MeSH terms

  • Female
  • Fertilization in Vitro
  • Follow-Up Studies
  • Humans
  • Hypothyroidism* / complications
  • Infant, Newborn
  • Kidney Transplantation* / adverse effects
  • Liver Cirrhosis, Biliary* / complications
  • Liver Cirrhosis, Biliary* / surgery
  • Lupus Erythematosus, Systemic* / complications
  • Pregnancy