A New Monoterpene from the Rhizomes of Alpinia galanga and Its Anti-Vpr Activity

Chem Biodivers. 2021 Oct;18(10):e2100401. doi: 10.1002/cbdv.202100401. Epub 2021 Sep 21.

Abstract

A new menthane-type monoterpene, alpigalanol (1), together with four known terpenes (2-5) were isolated from the ethyl acetate soluble fraction of the 70 % ethanol extract of the Alpinia galanga rhizomes. The structure of 1 was determined by spectroscopic analyses, including 1D- and 2D-NMR. The extract of the A. galanga rhizomes and all isolated compounds (1-5) possessed Vpr inhibitory activities against the TREx-HeLa-Vpr cells at a concentration of 1.25 μM without showing any cytotoxicity.

Keywords: Alpinia galanga; Viral protein R; monoterpene; sesquiterpene.

MeSH terms

  • Alpinia / chemistry*
  • Density Functional Theory
  • Dose-Response Relationship, Drug
  • Gene Products, vpr / antagonists & inhibitors*
  • HeLa Cells
  • Humans
  • Molecular Conformation
  • Monoterpenes / chemistry
  • Monoterpenes / isolation & purification
  • Monoterpenes / pharmacology*
  • Rhizome / chemistry*
  • Tumor Cells, Cultured

Substances

  • Gene Products, vpr
  • Monoterpenes