WWP1 targeting MUC1 for ubiquitin-mediated lysosomal degradation to suppress carcinogenesis

Signal Transduct Target Ther. 2021 Aug 18;6(1):297. doi: 10.1038/s41392-021-00660-x.
No abstract available

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Carcinogenesis / genetics
  • Carcinogenesis / metabolism*
  • Cell Line, Tumor
  • HEK293 Cells
  • Humans
  • Lysosomes / genetics
  • Lysosomes / metabolism*
  • Mucin-1 / genetics
  • Mucin-1 / metabolism*
  • Neoplasm Proteins / genetics
  • Neoplasm Proteins / metabolism*
  • Neoplasms / genetics
  • Neoplasms / metabolism*
  • Proteolysis*
  • Ubiquitin / genetics
  • Ubiquitin / metabolism*
  • Ubiquitin-Protein Ligases / genetics
  • Ubiquitin-Protein Ligases / metabolism*

Substances

  • Mucin-1
  • Neoplasm Proteins
  • Ubiquitin
  • WWP1 protein, human
  • Ubiquitin-Protein Ligases