Protein Phosphatase 2A Activation Via ApoER2 in Trophoblasts Drives Preeclampsia in a Mouse Model of the Antiphospholipid Syndrome

Circ Res. 2021 Sep 17;129(7):735-750. doi: 10.1161/CIRCRESAHA.120.318941. Epub 2021 Aug 18.

Haiyan Chu¹, Anastasia Sacharidou¹, An Nguyen¹, Chun Li¹, Ken L Chambliss¹, Jane E Salmon², Yu-Min Shen³, Julie Lo⁴, Gustavo W Leone⁵, Joachim Herz⁶, David Y Hui⁷, Denise K Marciano^{3

8}, Vikki M Abrahams⁹, Bryony V Natale^{10

11}, Alina P Montalbano¹², Xue Xiao¹³, Lin Xu¹³, David R Natale^{10

11}, Philip W Shaul¹, Chieko Mineo^{1

8}

¹ Center for Pulmonary and Vascular Biology, Pediatrics (H.C., A.S., A.N., C.L., K.L.C., P.W.S., C.M.).
² Medicine, Hospital for Special Surgery, Weill Cornell Medical College, New York (J.E.S.).
³ Internal Medicine (Y.-M.S., D.K.M.), University of Texas Southwestern Medical Center, Dallas.
⁴ Obstetrics and Gynecology (J.L.), University of Texas Southwestern Medical Center, Dallas.
⁵ Froedtert-Medical College of Wisconsin Cancer Center, Medical College of Wisconsin, Milwaukee (G.W.L.).
⁶ Molecular Genetics (J.H.), University of Texas Southwestern Medical Center, Dallas.
⁷ Pathology, University of Cincinnati College of Medicine (D.Y.H.).
⁸ Cell Biology (D.K.M., C.M.), University of Texas Southwestern Medical Center, Dallas.
⁹ Obstetrics, Gynecology & Reproductive Sciences, Yale School of Medicine, New Haven, CT (V.M.A.).
¹⁰ Obstetrics, Gynecology & Reproductive Science, University of California San Diego, La Jolla (B.V.N., D.R.N.).
¹¹ Obstetrics and Gynaecology, School of Medicine, Queen's University, Ontario, Canada (B.V.N., D.R.N.).
¹² Biochemistry and Obstetrics and Gynecology (A.P.M.), University of Texas Southwestern Medical Center, Dallas.
¹³ Population and Data Sciences and Pediatrics (X.X., L.X.), University of Texas Southwestern Medical Center, Dallas.

Abstract

[Figure: see text].

Keywords: antiphospholipid syndrome; endoglin; placenta; preeclampsia; proteinuria; trophoblasts.