Six new cadinane-type sesquiterpenoids from the leaves of Chimonanthus nitens Oliv

Fitoterapia. 2021 Oct:154:105019. doi: 10.1016/j.fitote.2021.105019. Epub 2021 Aug 14.

Abstract

Six new cadinane-type sesquiterpenoids, named Chimnitensin A-F (1-6) were isolated from the leaves of Chimonanthus nitens Oliv. Their structures were elucidated by comprehensive spectroscopic analyses and comparison with structurally related known analogues. In vitro MTT assay showed that all six compounds had cytotoxicity against two selected human breast cancer cell lines (MDA-MB-468 and MDA-MB-231), which indicate their potential of developing into anticancer drugs.

Keywords: Cadinane; Chimonanthus nitens Oliv.; Cytotoxicity; Sesquiterpenoids.

MeSH terms

  • Antineoplastic Agents, Phytogenic / isolation & purification
  • Antineoplastic Agents, Phytogenic / pharmacology*
  • Calycanthaceae / chemistry*
  • Cell Line, Tumor
  • China
  • Humans
  • Molecular Structure
  • Phytochemicals / isolation & purification
  • Phytochemicals / pharmacology
  • Plant Leaves / chemistry
  • Polycyclic Sesquiterpenes / isolation & purification
  • Polycyclic Sesquiterpenes / pharmacology*

Substances

  • Antineoplastic Agents, Phytogenic
  • Phytochemicals
  • Polycyclic Sesquiterpenes
  • cadinane