Low THRB (thyroid hormone receptor beta) Promoter Methylation Levels in Peripheral Blood Leukocytes Induced By Systematic Inflammation Are Involved in Low Thyroid Hormone Function in Metabolic Syndrome

Hypertension. 2021 Sep;78(4):1005-1015. doi: 10.1161/HYPERTENSIONAHA.121.17847. Epub 2021 Aug 15.

Abstract

[Figure: see text].

Keywords: THRB thyroid hormone; inflammation; metabolic syndrome; methylation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Animals
  • DNA Methylation*
  • Female
  • Humans
  • Inflammation / metabolism*
  • Insulin Resistance
  • Leukocytes / metabolism*
  • Male
  • Metabolic Syndrome / genetics
  • Metabolic Syndrome / physiopathology*
  • Middle Aged
  • Promoter Regions, Genetic*
  • Rats
  • Rats, Wistar
  • Thyroid Hormone Receptors beta / genetics*
  • Thyroid Hormones / physiology*

Substances

  • Thyroid Hormone Receptors beta
  • Thyroid Hormones