Immune Checkpoint Inhibitor-Associated Myocarditis With Persistent Troponin Elevation Despite Abatacept and Prolonged Immunosuppression

Shiying Liu; Joyce Chan; Davor Brinc; Sonal Gandhi; Aaron Izenberg; Diego Delgado; Husam Abdel-Qadir; Bernd J Wintersperger; Paaladinesh Thavendiranathan

doi:10.1016/j.jaccao.2020.10.013

Immune Checkpoint Inhibitor-Associated Myocarditis With Persistent Troponin Elevation Despite Abatacept and Prolonged Immunosuppression

JACC CardioOncol. 2020 Dec 15;2(5):800-804. doi: 10.1016/j.jaccao.2020.10.013. eCollection 2020 Dec.

Authors

Shiying Liu¹, Joyce Chan², Davor Brinc³, Sonal Gandhi⁴, Aaron Izenberg⁵, Diego Delgado¹, Husam Abdel-Qadir^{1

6}, Bernd J Wintersperger^{7

8}, Paaladinesh Thavendiranathan^{1

7}

Affiliations

¹ Ted Rogers Program in Cardiotoxicity Prevention, Peter Munk Cardiac Centre, Toronto General Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada.
² Department of Pharmacy, University Health Network, University of Toronto, Toronto, Ontario, Canada.
³ Department of Laboratory Medicine and Pathobiology, University Health Network, University of Toronto, Toronto, Ontario, Canada.
⁴ Division of Medical Oncology, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada.
⁵ Division of Neurology, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada.
⁶ Women's College Hospital, University of Toronto, Toronto, Ontario, Canada.
⁷ Joint Department of Medical Imaging, Toronto General Hospital, University Health Network, Toronto, Ontario, Canada.
⁸ Department of Medical Imaging, University of Toronto, Toronto, Ontario, Canada.

No abstract available

Keywords: AchR-Ab, acetylcholine receptor antibody; CMR, cardiovascular magnetic resonance; HF, heart failure; ICI, immune checkpoint inhibitor; LGE, late gadolinium enhancement; LVEF, left ventricular ejection fraction; MG, myasthenia gravis; MMF, mycophenolate mofetil; PD-1, programmed cell death receptor-1; PEG, polyethylene glycol; RR, reference range; abatacept; cardiovascular MRI; hsTnI, high-sensitivity troponin I; immune check point inhibitors; immunotherapy; macrotroponins; myasthenia gravis; myocarditis; troponin.

Publication types

Review