The Role of Long Noncoding RNA AL161431.1 in the Development and Progression of Pancreatic Cancer

Gang Ma; Guichen Li; Wufeng Fan; Yuanhong Xu; Shaowei Song; Kejian Guo; Zhe Liu

doi:10.3389/fonc.2021.666313

The Role of Long Noncoding RNA AL161431.1 in the Development and Progression of Pancreatic Cancer

Front Oncol. 2021 Jul 30:11:666313. doi: 10.3389/fonc.2021.666313. eCollection 2021.

Authors

Gang Ma¹, Guichen Li¹, Wufeng Fan¹, Yuanhong Xu¹, Shaowei Song¹, Kejian Guo¹, Zhe Liu¹

Affiliation

¹ Department of Pancreatic-Biliary Surgery, First Hospital of China Medical University, Shenyang, China.

Abstract

Pancreatic cancer is known for its notorious fast progression and poor prognosis. Long noncoding RNA (lncRNA) AL161431.1 has been reported to be involved in the pathogenesis of different cancers. In this study, we explored the role of lncRNA AL161431.1 in the development and progression of pancreatic cancer by bioinformatic analysis, in vitro and in vivo experiments in pancreatic cancer BxPC-3 and SW1990 cells, as well as clinical samples. We found that lncRNA AL161431.1 was highly expressed in pancreatic cancer cells and tissues. Knock down of lncRNA AL161431.1 led to increased cancer cell death and cell cycle arrest. Xenograft growth of SW1990 cells with stable knockdown of lncRNA AL161431.1 in mice was significantly slower than that of SW1990 cells with scrambled control shRNA. Finally, we showed the involvement of lncRNA AL161431.1 in pancreatic cancer was related to its promotion of epithelial mesenchymal transition process.

Keywords: bioinformatics; diagnosis; epithelial mesenchymal transition (EMT); long noncoding RNA; pancreatic cancer.