Molecular docking analysis of stevioside with Akt and PPARγ

Abilasha Deenadayalan; S Vijayalakshmi; C S Janaki; Selvaraj Jayaraman

doi:10.6026/97320630017283

Molecular docking analysis of stevioside with Akt and PPARγ

Bioinformation. 2021 Jan 31;17(1):283-288. doi: 10.6026/97320630017283. eCollection 2021.

Authors

Abilasha Deenadayalan^{1

2}, S Vijayalakshmi¹, C S Janaki³, Selvaraj Jayaraman⁴

Affiliations

¹ Department of Anatomy, Saveetha Medical College and Hospital, Saveetha Institute of Medical and Technical Sciences, Saveetha Nagar,Chennai-602105, India.
² Department of Anatomy, Asan Memorial Dental College and Hospitals, Asan Nagar, Chengalpattu, Chennai-602 105, India.
³ Department of Anatomy, Bharath Medical College and Hospital, Selaiyur, Chennai-600 073, India.
⁴ Department of Biochemistry, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai-600 077, India.

Abstract

Stevioside is a diterpenoid glycoside consisting of an aglycone (steviol) and three glucose molecules. It is commonly used as an anti-hyperglycemic food because of its non-caloric property. Therefore, it is of interest to document the interactions of stevioside with AKT & PPAR-γ proteins using Autodock Vina PyRx docking techniques. Results of the docking studies indicate that stevioside had more than two hydrogen bond interactions with the AKT and PPAR γ protein for further consideration.

Keywords: AKT & PPAR gamma; Diabetes; molecular docking; stevioside.