Identification of aspirin and diclofenac binding proteins in the red complex pathogens

Geethika Babu; Veeraraghavan Vishnu Priya; Pothapur Keshaav Krishnaa; Rengasamy Gayathri; Jayaseelan Vijayashree Priyadharsini

doi:10.6026/97320630017192

Identification of aspirin and diclofenac binding proteins in the red complex pathogens

Bioinformation. 2021 Jan 31;17(1):192-199. doi: 10.6026/97320630017192. eCollection 2021.

Authors

Geethika Babu¹, Veeraraghavan Vishnu Priya¹, Pothapur Keshaav Krishnaa¹, Rengasamy Gayathri¹, Jayaseelan Vijayashree Priyadharsini²

Affiliations

¹ Department of Biochemistry, Saveetha Dental College, Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveetha University, Chennai 600077, India.
² Biomedical Research Unit and Laboratory Animal Centre-Dental Research Cell, Saveetha Dental College, Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveetha University, Chennai 600077, India.

Abstract

Red complex organisms are a group of organisms (Porphyromonas gingivalis ATCC 33277, Treponema denticola ATCC 35405, Tannerella forsythia ATCC 43037) that have been identified for the causation of periodontal diseases. Aspirin and diclofenac have been used as regular analgesics. Therefore, it is of interest to document the identification of aspirin and diclofenac binding proteins in the red complex pathogens using the STITCH v.5 pipeline. The virulence properties of these proteins were analyzed using VICMPred and VirulentPred software. Thus, we document 000 number of proteins having optimal binding features with the known analgesics.

Keywords: aspirin; diclofenac; pathogens; proteins.