Biofluids profile of α-Klotho in patients with Parkinson's disease

Giulia Maria Sancesario; Giulia Di Lazzaro; Piergiorgio Grillo; Benedetta Biticchi; Emilia Giannella; Mohammad Alwardat; Massimo Pieri; Sergio Bernardini; Nicola Biagio Mercuri; Antonio Pisani; Tommaso Schirinzi

doi:10.1016/j.parkreldis.2021.08.004

Biofluids profile of α-Klotho in patients with Parkinson's disease

Parkinsonism Relat Disord. 2021 Sep:90:62-64. doi: 10.1016/j.parkreldis.2021.08.004. Epub 2021 Aug 10.

Affiliations

¹ Biobank Unit, IRCCS Fondazione Santa Lucia, Rome, Italy.
² Department of Systems Medicine, University of Roma Tor Vergata, Rome, Italy; Neurology Unit, IRCCS Fondazione Policlinico Universitario A. Gemelli, Rome, Italy.
³ Department of Systems Medicine, University of Roma Tor Vergata, Rome, Italy.
⁴ Department of Systems Medicine, University of Roma Tor Vergata, Rome, Italy; Allied Medical Science Department, Division of Physical Therapy, Aqaba University of Technology, Aqaba, Jordan.
⁵ Department of Experimental Medicine, University of Roma Tor Vergata, Rome, Italy.
⁶ Department of Systems Medicine, University of Roma Tor Vergata, Rome, Italy; IRCCS Fondazione Santa Lucia, European Centre for Brain Research, Rome, Italy.
⁷ Department of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy; IRCCS Mondino Foundation, Pavia, Italy.
⁸ Department of Systems Medicine, University of Roma Tor Vergata, Rome, Italy. Electronic address: t.schirinzi@yahoo.com.

PMID: 34392132
DOI: 10.1016/j.parkreldis.2021.08.004

Abstract

We measured α-Klotho in CSF and serum of PD patients at early stage of the disease, finding two distinct pools, the first increased, the second reduced. CSF α-Klotho was inversely associated with CSF α-synuclein levels. Our preliminary results suggest α-Klotho as potential biomarker or therapeutic target in PD.

Keywords: Biomarkers; Blood; CSF; Parkinson's disease; α-Klotho.

Publication types

Letter

MeSH terms

Biomarkers / blood
Biomarkers / cerebrospinal fluid
Case-Control Studies
Female
Humans
Klotho Proteins / analysis*
Male
Middle Aged
Parkinson Disease / blood*
Parkinson Disease / cerebrospinal fluid*
alpha-Synuclein / cerebrospinal fluid

Substances

Biomarkers
alpha-Synuclein
Klotho Proteins