Differential involvement of frontoparietal network and insula cortex in emotion regulation

Abstract

Emotion regulation (ER) is an essential part of our daily life. To effectively regulate emotions, different types of strategies may be adopted. Although previous neuroimaging studies have shown that the frontoparietal cortex is critical for the regulation of emotions, reports about the specific brain regions involved in each strategy remain inconsistent. Therefore, the present study recruited 32 healthy participants to directly examine three typical ER strategies (distraction, reappraisal, and suppression) with an emotional regulation paradigm using functional magnetic resonance imaging (fMRI). Our results show that the three ER strategies recruited differential activation in the frontoparietal and insular cortex. Specifically, distraction evoked stronger activation in the parietal cortex, while reappraisal triggered stronger activation in most parts of the frontal cortex. Importantly, suppression predominantly recruited the left inferior frontal gyrus (IFG), while reappraisal caused more activation than suppression in bilateral medial superior frontal gyrus and IFG. Besides, functional connectivity analysis found that the connectivity between the right insular and the right IFG was negatively correlated with reappraisal effect, while that between the left insular and the left IFG was negatively correlated with suppression effect. These results suggest that the successful implementation of distraction, reappraisal, and suppression specifically employ different parts of the frontoparietal network. Overall, our findings may have potential implications for clinical practice by providing specific neural targets for clinical intervention.

Keywords: Distraction; Functional connectivity; Reappraisal; Suppression; fMRI.