Autoimmune atrophic gastritis in systemic sclerosis

Deepti Avasthi; Jean Thomas; Leela Krishna Vamsee Miriyala; Salil Avasthi

doi:10.1136/bcr-2021-242851

Autoimmune atrophic gastritis in systemic sclerosis

BMJ Case Rep. 2021 Aug 13;14(8):e242851. doi: 10.1136/bcr-2021-242851.

Authors

Deepti Avasthi¹, Jean Thomas², Leela Krishna Vamsee Miriyala³, Salil Avasthi³

Affiliations

¹ Department of Internal Medicine, Mercy St Vincent Medical Center, Toledo, Ohio, USA dipti312@gmail.com.
² Department of Pathology, Mercy Saint Vincent Medical Center, Toledo, Ohio, USA.
³ Department of Internal Medicine, Mercy St Vincent Medical Center, Toledo, Ohio, USA.

Abstract

Systemic sclerosis (SSc) is a rare connective tissue disorder with a complex pathogenesis involving vascular dysfunction, small vessel proliferation as well as alterations of innate and adaptive immunity. Gastrointestinal (GI) involvement in SSc is almost universal and affects nearly 90% of the patients. Of all the GI manifestations, 30%-75% are oesophageal abnormalities, including gastro-oesophageal reflux disease, reflux oesophagitis and Barret's oesophagus. The incidence of gastric manifestations is about 22% with a common presentation of gastric antral vascular ectasia (GAVE). However, autoimmune atrophic gastritis (AIG) is not a known manifestation of SSc. Our case has a unique presentation of the coexistence of GAVE and AIG. We have conducted a thorough literature review to study a possible association of AIG and SSc and understand the pathology of SSc.

Keywords: gastroenterology; immunology; stomach and duodenum.

Publication types

Case Reports

MeSH terms

Esophageal Diseases*
Gastric Antral Vascular Ectasia*
Gastritis*
Gastritis, Atrophic* / complications
Humans
Scleroderma, Systemic* / complications